Co-Stimulation of T cells via CD28 inhibits human IgE production; reversal by Pertussis toxin

Stimulation of Dendritic Cells Pertussis Toxin Enhances Th1 Responses by

CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation.

CD28 is the quintessential costimulatory molecule expressed on CD4(+) and CD8(+) T cells. During chronic infections and the normal aging process, CD28 expression is lost, compromising the functional activity of T cells. CD28 loss is promoted by replicative stress, particularly in the presence of tumor necrosis factor-alpha, owing to an inoperative CD28 initiator element. It is currently unknown...

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8+ T Cells

Both CD28 and NKG2D can function as co-stimulatory receptors in human CD8+ T cells. However, their independent functional contributions in distinct CD8+ T cell subsets are not well understood. In this study, CD8+ T cells in human peripheral blood- and lung-derived lymphocytes were analyzed for CD28 and NKG2D expression and function. We found a higher level of CD28 expression in PBMC-derived naï...

CD28 co-stimulation in T-cell homeostasis: a recent perspective

T-cells play a key role within the adaptive immune system mediating cellular immunity and orchestrating the immune response as a whole. Their activation requires not only recognition of antigen/major histocompatibility complexes by the T-cell receptor but in addition co-stimulation via the CD28 molecule through binding to CD80, CD86, or as recently discovered, inducible co-stimulator ligand exp...

Phosphoinositide 3-kinase and CD28-mediated T-cell co-stimulation.

Introduction Activation of resting T lymphocytes requires at least two signals: one provided by engagement of the T-cell antigen receptor (TCR)-CD3 complex by foreign antigen associated with self-major histocompatibility complex and the second by costimulatory molecule(s) present on antigen presenting cells (reviewed in [l]) . These signals trigger the GO-G1 transition of the cell cycle as well...